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At Amgen, our mission is to serve patients. As a science-based, patient-focused organization, we discover and develop innovative therapies to treat serious illnesses.
Our medicines have made a dramatic difference in the lives of tens of thousands of Canadians. That is the most important measure of our success.
The following table provides the prescribing information for Amgen Canada’s major approved products. Due to differences in global labelling, this information is intended for residents of Canada only.
Canadian regulations limit the amount and scope of information we can provide on our prescription drugs. If you require more information you should consult a qualified health professional.
Welcome to your step-by-step guide to injecting with the Prolia prefilled syringe. This video is designed to help you administer your Prolia injection.
Welcome to your step-by-step guide to injecting with the Prolia prefilled syringe.
This video is designed to help you administer your Prolia injection.
If you’ve been prescribed Prolia, you can give yourself your injection as long as you have been properly trained. Let’s walk through the steps for self-injection together.
When you bring your Prolia prescription home from the pharmacy, store it in your refrigerator between 2 and 8 degrees Celsius until ready for use. Do not freeze Prolia.
Store Prolia in its original carton in order to protect it from light, and keep it out of the reach and sight of children.
When removed from the refrigerator, Prolia must be kept at room temperature, up to 25 degrees Celsius, in the original carton, and must be used within 30 days.
There are four steps when administering Prolia:
1. Preparing for administration
2. Getting ready to inject
3. Injecting with the syringe
4. And finishing and properly disposing of the used syringe
Before you get started, a quick note about the green safety guard you’ll see on the Prolia pre-filled syringe. For your safety, this safety guard should be manually activated after the injection is given.
Do not slide the green safety guard forward over the needle before administering the injection – it will lock in place and prevent injection. You would need to use another syringe that hasn’t been activated and is ready to use.
The prefilled syringe is not made with natural rubber latex. Now it’s time to prepare for your injection. First, take the Prolia carton out of the refrigerator. If the carton appears damaged or opened, do not use the syringe.
Carefully remove the syringe tray from the carton and set it on a clean, well-lit surface for 15 to 30 minutes before your injection to allow it to reach room temperature, about 25 degrees Celsius. This will make the injection more comfortable.
Don’t warm the syringe up in any other way. Allow it to gradually reach room temperature. Don’t leave the syringe in direct sunlight, or shake the syringe.
For safety reasons, don’t grab the plunger rod or the grey needle cap when removing the syringe from the carton.
Always hold the syringe by the syringe barrel. Don’t remove the grey needle cap until you’re ready to inject. Next, inspect the medicine and syringe. Make sure the medicine in the syringe is clear and colourless to light yellow.
Do not use if the solution is cloudy or discoloured; if any part appears cracked or broken; if the syringe has been dropped; if the grey needle cap is missing or not securely attached; or if the expiration date printed on the label has passed.
Do not use the syringe if it has been dropped on a hard surface. Part of the syringe may be broken even if you can’t see the break. In all cases, use a new syringe and call Amgen Medical Information at 1-866-502-6436.
Now, wash your hands thoroughly with soap and water, and gather all the materials you will need for your injection.
On a clean, well-lit work surface, place:
• one prefilled syringe
• an alcohol wipe
• a cotton ball or gauze pad
• an adhesive bandage
• and a sharps disposal container.
Next, prepare and clean the injection site. You can use the upper thigh; the stomach area except for a 2-inch, or 5 centimetre, area right around the navel; or the outer area of the upper arm, but only if someone else is giving you the injection.
Clean the injection site with an alcohol wipe. Let the skin dry. Do not touch this area again before injecting. Do not inject into areas where the skin is tender, bruised, red or hard. Avoid injecting into areas with scars or stretch marks.
Hold the prefilled syringe by the syringe barrel. When you’re ready to inject, pull the grey needle cap straight off and away from the body. Don’t twist or bend the cap or put it back on the syringe. Dispose of the cap in the sharps container.
Now you’re ready to inject Prolia. Pinch the skin at the injection site firmly between your thumb and fingers to create a firm surface.
It’s important that you keep the skin pinched while injecting. Holding the pinch, insert the needle into the skin at 45 to 90 degrees.
Using slow and constant pressure, push the plunger rod until it reaches the bottom, making sure to inject all the liquid. The syringe barrel should appear empty. Do not pull back the plunger rod while the needle is inserted.
When you’re done, gently pull the syringe off of the skin. When you remove the syringe, if it looks like the medicine is still in the syringe barrel, this means you have not received a full dose. Call your healthcare professional right away.
Before you finish, for your safety, pull the green safety guard until it clicks and locks into position to cover the needle. Keep your hands away from the needle at all times.
Dispose of the used syringe in the sharps container, never in the household trash. For instructions on how to dispose of your sharps container when full, and what kind of container may be used if you don’t have a sharps container, please see the Patient Medication Information leaflet that comes with your package.
It’s important to always keep the sharps container out of the reach of children. Do not reuse the syringe.
Finally, examine the injection site. If there is blood, press a cotton ball or gauze pad on the injection site. Do not rub the injection site. You can apply an adhesive bandage if you need to.
Prolia is administered every 6 months, so be sure to plan for your next injection when you complete your current one.
We hope this video has been helpful.
Visit www.Prolia.ca to learn more.
You will need the Prolia Drug Identification Number, or DIN, to access the website. The Prolia DIN is 02343541.
This video is an instructional guide through the 4 main steps for injecting the SureClick® single-use prefilled autoinjector from Repatha®.
Chapter I: Using Your REPATHA SureClick Autoinjector
Welcome! In this 9-chapter video, we’ll guide you through the steps for injecting Repatha, also known as evolocumab, with a single-use prefilled SureClick autoinjector. From here on, we’ll refer to it as the Repatha SureClick, or just the SureClick. This video highlights the four steps for injecting Repatha as outlined in your Patient Medication Information leaflet, which are 1) prepare, 2) get ready, 3) inject, and 4) finish. For complete injection information, please refer to the Patient Medication Information leaflet included in your Repatha package. It’s important that you do not inject yourself unless your healthcare provider has shown you how. If someone else is giving you the injection, he or she should also be trained first. If you’re still not sure how to use the Repatha SureClick, contact your doctor, or call the RepathaREADY® Program at 1-888-Repatha, that’s 1-888-737-2842. Okay, let’s get started.
Chapter II: Description of Autoinjector
The SureClick autoinjector is prefilled with a fixed dose and is single-use, so if used correctly, you will know that you are getting the dose your doctor has prescribed. At this end, the orange cap covers and fits inside the yellow safety guard. The yellow safety guard automatically covers the needle after injection. The needle is hidden before, during, and after injection. Do not remove the orange cap until you are ready to start the injection. At the other end you will find the grey start button. When you press the start button, you will hear a click, like this, as the injection begins. Do not press the button until you are ready to inject your medicine. And here in the middle is the inspection window. It turns yellow when the injection is complete so you know the full dose was given.
Chapter III: Storage
First, it’s important to store Repatha the right way. That means keeping it refrigerated in its original box to protect it from light and physical damage. Take one SureClick out of the box from the refrigerator at least 30 minutes before injecting. Let it reach room temperature naturally. Leave any unused autoinjectors in the box in the refrigerator. You can also keep Repatha at room temperature, up to 25°C, in the original carton, as long as it is used within 30 days. Be careful not to leave it in the extreme heat or cold, and don’t freeze or shake it. Do not use Repatha SureClick beyond the expiration date. And remember to keep Repatha® out of children’s reach and sight like you would with any medicine.
Chapter IV: Inspecting Your Autoinjector
Give your Repatha SureClick the “once-over” before using it. Check the expiration date. You don’t want to use an expired SureClick. Look for any cracks and check that the orange cap is in place, securely attached. Never use a SureClick that is cracked, missing the orange cap, or that was dropped onto a hard surface. Next, look at the medicine in the SureClick window. It should be clear and colourless. But it’s okay if the medicine is slightly yellow. If you have any questions about using your Repatha SureClick, call your doctor, pharmacy, or 1-888-Repatha, that’s 1-888-737-2842. Okay, your Repatha SureClick looks good, and it’s been 30 minutes since you took it out of the refrigerator. Now, it’s time to get ready for your injection.
Chapter V: Gather Your Materials
Make sure you’ve washed your hands. Next, choose a comfortable spot with plenty of light. Gather all of your injection supplies, including a new Repatha SureClick, alcohol wipes, cotton ball, an adhesive bandage, and the puncture-resistant sharps disposal container. Place them on a clean, flat work surface.
Chapter VI: Choosing Your Injection Site
Now, choose where you want to inject. You can use your thigh or your stomach, except for the 2 inches around the belly button. If someone else is giving you the injection, he or she can also use the outer area of your upper arm. Choose a different site each time you give yourself an injection. If you do need to use the same injection site, just make sure it’s not in the same spot on that site you used last time. And always avoid areas where the skin is bruised or hard. We’re going to show you how to inject in your thigh. If you would like to see how to inject in other areas, check out the Patient Medication Information leaflet included in your Repatha® package.
Chapter VII: Push, Press, Watch, and Confirm
Alright. First, clean the injection site with an alcohol wipe. Let it dry. And don’t touch this area again until you’re ready to inject. Next, pull the orange cap straight off, like this. If you see a drop of liquid at the end of the needle, that’s okay. Next, stretch the skin on your thigh to create a firm surface. Like this. You can also pinch your skin to administer the injection. It’s important to keep your skin tight throughout the injection. Review the key injection steps before completing your injection. Now, place the Repatha SureClick on your thigh at a 90-degree angle. Be sure you can see the medication window. Remember to keep your skin tight. Push the Repatha SureClick down firmly onto your skin until it stops moving. When you’re ready to inject, press the grey start button. You will hear a click. That means your injection has started. Keep pushing the Repatha SureClick down on your skin. The injection could take about 15 seconds to complete. If you did not hear a second click or if you’re not sure that your injection is finished, check the Repatha SureClick window. It will turn yellow when the injection is done. Lift the used SureClick from your skin. The safety guard will automatically cover the needle. That’s it. You’re done injecting!
Chapter VIII: Dispose
Always put the used Repatha SureClick and orange cap into the sharps disposal container. You never want to put the used SureClick into the garbage or recycle bin. Talk with your doctor about proper disposal. There may be special provincial or local laws for disposal. Once you’ve properly disposed of your used SureClick, check your injection site. If you have a little bleeding, press a cotton ball or gauze on the injection site. Just be careful not to rub it. You can put a bandage on it if you need to.
Chapter IX: Important Safety Information
You’re all done! Remember, if you have any questions about injecting, read the instructions in the Patient Medication Information leaflet included in your Repatha package. Or, call your Care Coordinator at the RepathaREADY Program at 1-888-Repatha, that’s 1-888-737-2842.