×

Do you want to link to the external site and leave Amgen.ca?

You are now leaving the Amgen Canada website. Please note that the information you are about to view may not comply with Canadian regulatory requirements. Marketing authorizations and availability of products may differ between Canada and other countries.

×

Do you want to link to our other external sites and leave Amgen.ca?

You are now leaving the Amgen Canada website. Please note that the information you are about to view may not comply with Canadian regulatory requirements. Marketing authorizations and availability of products may differ between Canada and other countries.

Fracture Risk and Mortality Following a Fragility Fracture

Real-world evidence suggests Canadian healthcare professionals and patients need to pay closer attention to fractures caused by osteoporosis, as they can mean greater risks for subsequent breaksi and even death.ii Specifically, two recent Canadian studies supported by Amgen illustrate how critical it is to proactively assess and treat osteoporosis:

  • Fragility fracture identifies patients at imminent risk for subsequent fracture: real-world retrospective database study in Ontario, Canada
    This study of Canadians older than 65 concluded that those who experienced a fragility fracture are at imminent risk of experiencing a subsequent fracture within the next 2 years and should be proactively assessed and treated.iii

  • Mortality in older adults following a fragility fracture: real-world retrospective matched-cohort study in Ontario
    This study of Canadians older than 65 confirmed that a fragility fracture is associated with increased mortality risk. In fact, survival declined over the six years following the fracture with the steepest reduction occurring within the first year, when mortality risk more than doublediv and deaths were observed in 1 in 8 women with fractures and 1 in 5 men with fractures.v

These studies support the need to recognize first fractures caused by osteoporosis as an important risk factor for subsequent fracture and even death.

Despite this demonstrated risk and according to Osteoporosis Canada, only about 20% of fragility fracture patients in Canada currently undergo diagnosis and treatment for osteoporosis to help reduce the risk of subsequent fractures.vi, vii, viii

In order to effectively address this gap, it is important to provide education related to fracture and mortality risk to both medical and non-medical professionals involved in treating and/or caring for those who have experienced a fracture due to osteoporosis.ix

  1. Jonathan D. Adachi et al, Fragility fracture identifies patients at imminent risk for subsequent fracture: real-world retrospective database study in Ontario, Canada
  2. Jacques P. Brown et al, Mortality in older adults following a fragility fracture: real-world retrospective matched-cohort study in Ontario; paper still to be published
  3. Jonathan D. Adachi et al, Fragility fracture identifies patients at imminent risk for subsequent fracture: real-world retrospective database study in Ontario, Canada
  4. Jacques P. Brown et al, Mortality in older adults following a fragility fracture: real-world retrospective matched-cohort study in Ontario; paper still to be published
  5. Jacques P. Brown et al, Mortality in older adults following a fragility fracture: real-world retrospective matched-cohort study in Ontario; paper still to be published
  6. Osteoporosis Canada Fast Facts https://osteoporosis.ca/about-the-disease/fast-facts/ Accessed Nov 4, 2020
  7. Osteoporosis Canada Make the First Break the Last with Fracture Liaison Services
  8. 2010 Osteoporosis Guidelines
  9. Huntjens KM, van Geel TC, Geusens PP, Winkens B, Willems P, van den Bergh J, et al. Impact of guideline implementation by a fracture nurse on subsequent fractures and mortality in patients presenting with non-vertebral fractures. Injury. 2011;42 Suppl 4:S39-43.
    Hawley S, Javaid MK, Prieto-Alhambra D, Lippett J, Sheard S, Arden NK, et al. Clinical effectiveness of orthogeriatric and fracture liaison service models of care for hip fracture patients: population-based longitudinal study. Age Ageing. 2016;45(2):236-42.
    Metcalfe D, Zogg CK, Judge A, Perry DC, Gabbe B, Willett K, et al. Pay for performance and hip fracture outcomes: an interrupted time series and difference-in-differences analysis in England and Scotland. Bone Joint J. 2019;101-B(8):1015-23.
    Gonzalez-Quevedo D, Bautista-Enrique D, Perez-Del-Rio V, Bravo-Bardaji M, Garcia-de-Quevedo D, Tamimi I. Fracture liaison service and mortality in elderly hip fracture patients: a prospective cohort study. Osteoporos Int. 2020;31(1):77-84.

© 2016-2019 Amgen Inc. All rights reserved.

Privacy Policy Terms of Use